What is Vitamin B12?

Vitamin B12 is essential in maintaining normal nerve cell activity. The water-soluble mineral also assists in DNA replication and the production of the mood-affecting substance, SAMe (s-Adenosyl-l-Methionine).  Vitamin B12 also plays a major role with its partners Folic Acid and Vitamin B6 to control dangerous homocysteine levels which can increase risk of heart disease and stroke.


Anemia is usually (but not always) the first sign of B12 deficiency. Earlier in this century, doctors coined the name “pernicious anemia” for a stubborn form of anemia that didn’t improve even when the patient was given iron supplements.  Vitamin B12 deficiency can also cause nerve damage and this can, in some cases, occur without anemia first developing.


How does it work?

Vitamin B12 aids in the production of DNA and RNA, the body’s genetic material.  B12 supplementation can improve sperm count and motility.


Where does it come from?

Vitamin B12 is found in all foods of animal origin, such as dairy, eggs, poultry and fish.  However, it is also believed B12 can also be found in seaweed.


Safety / Side Effects

Oral vitamin B12 supplements are not generally associated with any side effects.


Studies Involving Sperm

CH3-B12 was administered daily (1,500 micrograms/day, for 4 to 24 weeks) to 26 infertile male patients from January to December, 1982.  Study was conducted from 8 weeks after the administration of CH3-B12.  Sperm concentration increased in 10 cases while total sperm counts increased in 14 cases (53.8%). Sperm motility increased in 13 cases (50.0%) and total number count increased in 13 cases (50.0%).



Certain medicines may interact with Vitamin B12.  Consult with your physician or pharmacist to determine if your medications might interact with this supplement.



Isoyama R, Baba Y, Harada H, Kawai S, Shimizu Y, Fujii M, Fujisawa S, Takihara H, and Sakatoku J. Clinical Experience of Methylcobalamin (CH3-B12)/Clomiphene Citrate Combined Treatment in Male Infertility. PMID: 3788744 (PubMed – indexed for MEDLINE). Hinyokika Kiyo. 1986 Aug;32(8):1177-83.